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Avid Pro Tools 12 is expected to be released in February 2015, however industry experts are saying a May 2015 launch date is more realistic.
The Mbox 2 is not qualified for Pro Tools 12. It may still work but I think mileage may vary. Pro Tools 12 does work without an audio interface that is if you only need it to mix and edit audio and are happy with monitoring via headphones or with speakers plugged into the on board soundcard of your computer.
This is a PCi-e card so it will fit in to a full size PC. You will need to check if CS6 will see it as a video source, You can always use the free BM software to record. It would, however be best to record on an SxS card in the camera and import it in to CS6 using USB